Liposomal vs. Nano-Emulsified CBD: What’s the Exact Difference


CBD products have gained immense popularity in the last five years. As the stigma attached to Marijuana is getting detached, and more and more countries and states are legalizing marijuana products in their respective regions, the CBD market gets a major push.

Along with the range of CBD products, there are different types & intake methods of CBD, including Liposomal CBD oil and Nano-Emulsified CBD oil, to name a few.

This article covers these primary methods and explains how both these methods are different from each other, their pros and cons and which one is a better option for you. This information will certainly help you buy the right CBD products in order to get the optimum results.

But before we learn the difference between Liposomal Oil CBD and Non-Emulsified CBD Oil, let us first understand what CBD is.

What is CBD?

CBD stands for cannabidiol– one of the 113 identified chemical compounds found in cannabis plants. CBD accounts for up to 40% of the plant extract. Various research and studies conducted on CBD establish that it has many salient medicinal properties like antibacterial, anti-inflammatory, anti-oxidative, and antifungal, among others.

All these properties make CBD a wonderful drug that cures, alleviates, and controls various diseases, conditions, and disorders. Some of the notable health benefits of CBD are:

  • CBD may reduce inflammation,
  • CBD may relieve chronic pain
  • CBD may reduce vomiting and nausea
  • CBD may promote immune system functions
  • CBD may suppress muscle spasms
  • CBD may relieve anxiety
  • CBD may promote better sleep
  • CBD may remove mental blocks
  • CBD may control epileptic seizures
  • CBD may boost collagen production, and
  • CBD may fight digestive and bowel disorders.

These are some of the most known physical and mental health benefits of CBD. Along with these key benefits, CBD also offers a range of skin health benefits and neurological benefits.

The other known compound that is found in cannabis plants is THC– which stands for tetrahydrocannabinol. THC is the principal psychoactive compound that produces the ‘high’ on consumption. But unlike THC, CBD does not create any high.

Moreover, all the CBD products contain a permissible and minimal amount of THC– 0.3%. Therefore, CBD products are entirely safe to consume and do not have any side effects. However, it is recommended that you always consult a doctor before you start CBD dosage.

Moreover, there are many CBD products of different forms available in the market, such as CBD tinctures, CBD edibles, CBD oil, CBD topicals, CBD vape, CBD pet products, Liposomal CBD oil, Nano-emulsified CBD, etc.

Such a wide range of products empowers you to choose the best product based on your convenience and choice. For example, if you want immediate action, CBD tinctures might be a good choice for you. Likewise, CBD edibles are good options if you are traveling much.

We hope this basic but necessary information about the CBD has helped you understand what CBD is and why it’s a rage among people of all ages.

Now let us learn what Liposomal CBD is.

What is Liposomal CBD?

The word liposomal consists of two Greek words: lipos, meaning fat, and soma, meaning body. Liposomal has a fatty tail that helps the body absorb the nutrient compounds that are encapsulated into vitamins, pharmaceuticals, or CBD.

In a more scientific term, liposomal can be defined as the spherical shells made up of a double layer of fatty acids. This set of fatty acid layers can be used to encapsulate pharmaceutical or CBD to provide them protection against dangerous stomach acids. The known example of liposomal is Liposomal vitamin C.

This technology has been used in the supplement industry for years but is comparatively new to the CBD industry.

Doctors recognize liposomal as the potential means to deliver nutrients.

Liposomal CBD oil provides many benefits as a drug delivery system, including biocompatibility, flexibility for active targeting, reduced toxicity of encapsulated drugs, self-assembly capability, and the ability to carry large drug payloads, among others.

As the liposomes are more easily and quickly recognized by the body, it improves the bioavailability of the CBD liposomal oil.

The importance of Liposomal CBD oil can be understood by this example– when we ingest any drugs or vitamins, the body metabolizes them through the digestive system. As it passes through several phases and takes longer to reach the damaged organ, the potency of the medicine is reduced, and hence the body does not receive the full dose of CBD oil.

In the case of Liposomal CBD oil, the nutrients are absorbed by the body more fluently. As the liposomal CBD bypasses the digestive system and gets directly in contact with the body or damaged organ, it offers a higher absorption level.

Most of the CBD websites and companies now produce Liposomal CBD products to ensure maximum absorption and efficacy into the body.

But there is a little problem with Liposomal. It is believed that Liposomal CBD may produce an uneven mixture resulting in some doses having more CBD than others. For this reason, there’s another advanced delivery method known as Nano-Emulsified CBD.

Let us learn what Nano-Emulsified CBD is.

What is Nano-Emulsified CBD?

Nano-emulsion is an advanced type of delivery system for oil-based common additives.

Nano-emulsification is a mechanism in which CBD molecules are spun into small particles that move easily through the cell walls of our body. The nutrients, vitamins, or CBD oil droplets are so little, but together they have a larger surface area that allows the body to optimize absorption and efficacy.

The absorption rate of nano-emulsified CBD is greater than that of liposomal CBD. Nano-emulsified CBD consists of much smaller molecules than those present in liposomal CBD oil.

Nano-emulsified compounds get absorbed at higher rates in the body compared to most of the other delivery methods.

When buying CBD oil, the particle size of CBD is a significant factor. Nano-emulsified droplets of CBD oil have an average size of 25-30 nanometers. In comparison, droplets of liposomal CBD oil are estimated at between 100-5000 nanometers.

Due to such a small size, CBD oil droplets can quickly enter the bloodstream, get more readily absorbed by the body, and heal the damaged organ.

The Differences Between Liposomal CBD Oil and Nano-Emulsified CBD Oil

The above two sections may have helped you get an idea about what liposomal CBD oil is and what nano-emulsified oil delivery processes are. Now let us learn how these methods are different from each other and their pros and cons.

Particle size, onset time, bioavailability, absorption rate, and dosage concentration are some of the major factors that distinguish these two methods.

A. Liposomal CBD Oil Vs. Nano-Emulsified CBD Oil: Droplet Size

The particle size of CBD plays a vital role in its efficacy. Smaller droplets of CBD oil have the comparatively larger surface area, and they can easily enter the bloodstream. Smaller particles are easily absorbed by the body and therefore offer greater efficacy.

The people who are well aware of this factor or the people who are pro users of CBD products often check this parameter while buying CBD products.

Liposomal CBD oil has a particle size between 100-5000 nanometers. Whereas, Nano-emulsified CBD oil has a particle size between 10-25 nanometers.

B. Liposomal CBD Oil Vs. Nano-Emulsified CBD Oil: Bioavailability

Bioavailability refers to the extent and rate at which the active drug or metabolite enters the body, and accesses the damaged or affected organ. For example, if you are taking a medicine for a headache, how much of it reaches the affected organ– the head, determines the bioavailability of the drug.

Every medicine has a different bioavailability level. This level determines the frequency and amount of medication dosage.

Liposomal CBD oil has a 35% bioavailability level. On the other hand, Nano-emulsified CBD oil has more than 50% bioavailability level.

C. Liposomal CBD Oil Vs. Nano-Emulsified CBD Oil: Absorption Rate

As the name suggests, the drug absorption rate is the parameter that refers to the way a drug is absorbed from a pharmaceutical formulation into the body. Higher absorption rate provides immediate and maximum effect while slow absorption rate offers late and comparatively lower results.

The drug absorption rate can be affected by various factors, including solubility, particle size, drug formulation, administration route, and gastric emptying rate.

Because of small particles and higher solubility, liposomal CBD oil has a higher absorption rate than Liposomal CBD oil.

D. Liposomal CBD Oil Vs. Nano-Emulsified CBD Oil: The onset of Action

The onset of action is the amount of time a drug takes for its effects to come to prominence following administration. It usually takes 20 minutes to an hour for oral administration, while it took a little longer for other types of administration.

Onset time is a very determinant factor for a disease where immediate actions are required, such as seizure. It is not feasible to wait for a long time to get relief in such conditions.

Liposomal CBD oil has an onset time of between 30 minutes to 1 hour. On the other hand, Nano-emulsified CBD oil has an onset time between 15-30 minutes.

E. Liposomal CBD Oil Vs. Nano-Emulsified CBD Oil: Dosage Concentration

It is necessary that CBD mixes well and even with the oil to produce symmetric effects throughout every dosage. If it doesn’t mix evenly, the results of each dose will vary to a small or a large extent even though you consume the same amount of CBD oil.

As mentioned earlier, Liposomal CBD oil may produce an uneven mixture resulting in some doses having more CBD than others. In comparison, Nano-emulsified CBD oil makes an equal mixture resulting in all doses having the same amount of CBD.

This can be well understood by the fact that if you took 10 mg of liposomal CBD oil on day 1, you might get 2mg of CBD out of it. But if you took the same amount of CBD– 10mg of CBD oil on day 2, the amount of CBD may vary a bit– it might be less than 2 mg or more than 2 mg.

While in the case of Nano-emulsified CBD oil, the amount of CBD remains the same in every dosage.

Liposomal vs. Nano-Emulsified CBD– Which is Better?

We would recommend Nano-emulsified CBD oil because it offers a greater absorption rate. A greater absorption rate means you have to use less CBD oil, making your CBD oil bottle last longer. Likewise, Liposomal CBD oil has a lower absorption rate, and hence the bottle gets empty earlier.

Besides, you get more value in purchasing Nano-emulsified CBD oil because more of the CBD will be absorbed into your body, so you don’t have to use it much. In other words, taking 5 mg of liposomal CBD is not the same as taking 5 mg of nano-emulsified CBD.

Rather, you will have to take more liposomal CBD to get the effects similar to that of nano-emulsified CBD. While liposomal CBD oil is beneficial in certain ways, Nano-emulsified CBD offers a greater absorption rate making it the best choice for most people.


As the CBD market is gaining momentum after the liberalization spree across the world in the last year, more and more CBD products, techniques, and delivery processes are being innovated every day. It is necessary that being a responsible CBD consumer, you know the CBD products well in order to get the maximum results. We hope that next time you go out for CBD purchase, you will have a clear idea about your needs, and you know which delivery process is best for you, ie, liposomal CBD oil or Nano-emulsified oil.